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However, China's dominance in rutile titanium dioxide manufacturing is not without challengeschina rutiletitanium dioxide manufacturer. Environmental concerns have become a major issue in recent years, as the industry's rapid expansion has put pressure on natural resources and ecosystems. To address these challenges, Chinese authorities have implemented stricter environmental regulations and encouraged the adoption of cleaner production technologies. These efforts have helped to improve the industry's environmental performance and ensure sustainable growth.

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In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.”  The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.

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