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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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The majority of the world's production of titanium dioxide goes into the manufacturing of paints, coatings, plastics, paper, and ink. As a pigment, it boasts high refractive index properties that provide exceptional opacity and brightness, making it ideal for enhancing the durability and appearance of products. Moreover, titanium dioxide's stability and ability to withstand high temperatures mean it can be used in exterior paints designed to resist fading caused by sunlight exposure.

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  • A Lawsuit Claims Skittles Are Unfit for Consumption. Experts Weigh in, by Rachel Rabkin Peachman, The New York Times, July 26, 2022

  • O'Brien, W.J. (1915). The Study of Lithopone. J. Phys. Chem19 (2): 113–144. doi:10.1021/j150155a002..