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The safety of food-grade titanium dioxide, or E171, lies in its ultrafine particle size. These particles are too small to be absorbed by the human body, passing through the digestive system without causing harm. Extensive research has been conducted to confirm this, with studies showing no evidence of genotoxicity or carcinogenicity. However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluations However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluations However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluations However, recent concerns about potential effects from nano-sized particles have led to ongoing evaluationsfood safe titanium dioxide.

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Apart from proximately neuromorphic technologies, TiO2-based memristors have also found application in various sensors. The principle of memristive sensorics is based on the dependency of the resistive switching on various external stimuli. This includes recording of mechanical energy (Vilmi et al., 2016), hydrogen detection (Hossein-Babaei and Rahbarpour, 2011Strungaru et al., 2015Haidry et al., 2017Vidiš et al., 2019), γ-ray sensing (Abunahla et al., 2016), and various fluidic-based sensors, such as sensors for pH (Hadis et al., 2015a) and glucose concentration (Hadis et al., 2015b). In addition, TiO2 thin films may generate photoinduced electron–hole pairs, which give rise to UV radiation sensors (Hossein-Babaei et al., 2012). Recently, the biosensing properties of TiO2-based memristors have been demonstrated in the detection of the bovine serum albumin protein molecule (Sahu and Jammalamadaka, 2019). Furthermore, this work has also demonstrated that the introduction of an additional graphene oxide layer may effectively prevent the growth of multidimensional and random conductive paths, resulting in a lower switching voltage, better endurance, and a higher resistance switching ratio. This opens up a new horizon for further functional convergence of metal oxides and two-dimensional memristive materials and interfaces (Zhang et al., 2019a).

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