microbar titanium dioxide supplier

In a 2020 study published in the Journal of Trace Elements in Medicine and Biology, researchers conducted an in vitro experiment to analyze the effects of TiO2 nanoparticles on a human neuroblastoma (SH-SY5Y) cell line. The scientists evaluated “reactive oxygen species (ROS) generation, apoptosis, cellular antioxidant response, endoplasmic reticulum stress and autophagy.” The results showed that exposure to the nanoparticles “induced ROS generation in a dose dependent manner, with values reaching up to 10 fold those of controls. Nrf2 nuclear localization and autophagy also increased in a dose dependent manner. Apoptosis increased by 4- to 10-fold compared to the control group, depending on the dose employed.” 

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Titanium dioxide production begins with the extraction of raw materials, typically ilmenite or rutile, from mines. In a white titanium dioxide factory, these minerals undergo a rigorous refining process that includes steps like sulfuric acid digestion, chloride process, or sulfate process, depending on the factory's technology and resources. The resulting titanium dioxide pigment is then purified, dried, and ground to achieve the desired particle size and quality.

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