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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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Despite its numerous advantages, the use of titanium dioxide in paint manufacturing requires careful consideration of its cost and availability. The mining and processing of TiO2 can be resource-intensive, which affects the final price of the paint product. However, ongoing research and development in the industry aim to optimize production processes, reduce costs, and explore alternatives like nano-titanium dioxide to further enhance paint performance.

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