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Inductively coupled plasma-optical emission spectrometry (ICP-OES) is another popular method for determining barium in TiO2. This technique uses an inductively coupled plasma to ionize the sample and then measures the intensity of light emitted by the resulting ions. ICP-OES offers high sensitivity and wide dynamic range, allowing for the detection of trace amounts of barium. It also requires specialized equipment, but its automation capabilities can reduce costs and improve efficiency.

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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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