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At the present JECFA meeting, the committee considered additional toxicological studies relevant to the safety assessment of the chemical that investigated its toxicokinetics, acute toxicity, short-term toxicity, long-term toxicity and carcinogenicity, genotoxicity, and reproductive and developmental toxicity, as well as special studies addressing its short-term initiation/promotion potential for colon cancer. The experts acknowledged that a large number of toxicological studies have been conducted using test materials, including nanoparticles, having size distributions and physico-chemical properties not comparable to real-world uses of titanium dioxide as a food additive. The studies on non-representative materials were evaluated by JECFA, but the committee concluded that such studies are not relevant to the safety assessment of the additive.

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Titanium dioxide, also known as TiO2, is a white pigment that is highly stable and non-toxic. It is commonly used in paints, plastics, papers, and cosmetics due to its excellent brightness and high refractive index. In the paint industry, titanium dioxide is added to enhance the opacity and durability of the product, ensuring long-lasting protection for surfaces. Manufacturers rely on this pigment to produce high-quality paints that meet customer demands for superior performance and aesthetic appeal.

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