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In a 2020 study published in the Journal of Trace Elements in Medicine and Biology, researchers conducted an in vitro experiment to analyze the effects of TiO2 nanoparticles on a human neuroblastoma (SH-SY5Y) cell line. The scientists evaluated “reactive oxygen species (ROS) generation, apoptosis, cellular antioxidant response, endoplasmic reticulum stress and autophagy.” The results showed that exposure to the nanoparticles “induced ROS generation in a dose dependent manner, with values reaching up to 10 fold those of controls. Nrf2 nuclear localization and autophagy also increased in a dose dependent manner. Apoptosis increased by 4- to 10-fold compared to the control group, depending on the dose employed.” 

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Another reputable TiO2 supplier is Chemours, a leading titanium technologies company that offers a comprehensive portfolio of TiO2 products. Chemours' Ti-Pure™ brand is widely recognized for its superior quality and performance, making it a preferred choice for many industries. With a global presence and a commitment to sustainable practices, Chemours is a reliable partner for companies looking to source high-quality TiO2 products.

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Are you looking for expert manufacturing and other marketing company that is specialized in powder products? Then you try with Foshan Xintu Chemical Co. LTD. Our company was recognized in the year 1988, and we committed to working with full attention to delivering quality chemical powder with standard quality at every time. We are a certified and topmost titanium dioxide manufacturer company with many years of experience, and we linked with different industries and another customer to deliver the best powder.

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From studies deemed relevant, the experts found that titanium dioxide as a food additive is poorly absorbed by the gastrointestinal tract of mice and rats, with no adverse effects observed in short-term studies in rodents receiving titanium dioxide in their diets. No observed adverse effect levels (NOAELs) of 15,000 milligrams per kilogram of bodyweight (mg/kg BW) per day and 5,000 mg/kg BW per day—the highest doses tested—were established for mice and rats, respectively.

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