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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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To address this challenge, many manufacturers are turning to biotechnology as a viable solution. Bioprocesses, such as the use of microorganisms or enzymes, offer a more sustainable alternative to traditional chemical methods. These processes can significantly reduce the amount of energy and chemicals required, while also generating fewer byproducts These processes can significantly reduce the amount of energy and chemicals required, while also generating fewer byproducts These processes can significantly reduce the amount of energy and chemicals required, while also generating fewer byproducts These processes can significantly reduce the amount of energy and chemicals required, while also generating fewer byproductsr 5566 titanium dioxide factories.

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