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In a 2020 study published in the Journal of Trace Elements in Medicine and Biology, researchers conducted an in vitro experiment to analyze the effects of TiO2 nanoparticles on a human neuroblastoma (SH-SY5Y) cell line. The scientists evaluated “reactive oxygen species (ROS) generation, apoptosis, cellular antioxidant response, endoplasmic reticulum stress and autophagy.” The results showed that exposure to the nanoparticles “induced ROS generation in a dose dependent manner, with values reaching up to 10 fold those of controls. Nrf2 nuclear localization and autophagy also increased in a dose dependent manner. Apoptosis increased by 4- to 10-fold compared to the control group, depending on the dose employed.” 

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When it comes to titanium dioxide, Pretiox is a name that stands out in the industry. As one of the leading manufacturers of this essential chemical compound, Pretiox has been at the forefront of quality and innovation for years. With a strong commitment to excellence and a passion for continuous improvement, Pretiox has earned a reputation for producing some of the highest quality titanium dioxide products on the market.

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