The major restraint to the global Lithopone market is the availability of numerous white pigment substitutes. It can be replaced by other inorganic white pigments such as Titanium Dioxide (TiO2) and Sachtolith. Among these substitutes, the introduction of TiO2 has reduced the commercial importance of Lithopone white pigment. Compared to other white pigments, TiO2 has high brightness and refractive index, which results in lower pigment loading. 

Research has shown that, when ingested as a food additive, titanium dioxide and its nanoparticles can impact, alter, and/or damage important protective bacteria in the gut, along with the metabolic pathways of gut bacteria.

Plus, titanium dioxide is chemically inert, meaning it won't react with other substances in the paint. This stability ensures that the paint retains its original color and properties over time, preventing discolouration and degradation. Using titanium dioxide as an ingredient, the paint can withstand harsh weather conditions and prevent flaking, peeling or chalking. This exceptional durability makes it ideal for interior and exterior walls, ensuring a long-lasting and beautiful finish.