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In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”

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In conclusion, CAS 13463-67-7, representing 99% pure titanium dioxide powder, is an indispensable raw material pigment across multiple industries. Its versatility, combined with its exceptional optical and protective properties, has made it a go-to choice for formulators and manufacturers seeking to enhance the performance and aesthetics of their products. The bulk availability of this compound underscores its importance in meeting the demands of large-scale production, ensuring a reliable source for global industries.

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