In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.” The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.
3. What is EFSA saying in its 2021 opinion on the safety of titanium dioxide as a food additive?
Importantly, TiO2 also has a very high refractive index (its ability to scatter light), even higher than diamond. This makes it an incredibly bright substance and an ideal material for aesthetic design use.
You can find more information about EFSA’s work in the area of food additives on our website
4. Should I stop eating products that contain TiO2?
Authors would like to mention that aditional experimental details, spectra and pictures are available from the corresponding author on reasonable request.


After drying, the sample is weighed precisely, and through stoichiometric calculations, the amount of titanium dioxide in the original sample can be determined
. The resulting calculation helps determine the gravimetric percentage of titanium dioxide present, providing manufacturers with critical information for quality control.What's the Verdict?
Tioxide process. This process is similar to that used to produce fumed silicas. Ultra-low particle size titanium dioxide (15-35 nm) is obtained for use as photocatalyst or UV absorber (for instance in sun protective creams).

Is titanium dioxide illegal in other countries?
Titanium dioxide is not unfamiliar to those involved in the chemical industry. Titanium dioxide is currently the highest-quality white pigment in the world, mainly used in plastics, coatings, paper, ink, chemical fiber, cosmetics and other industries. So what are the top five brands of titanium dioxide in China with good reputation? Let’s take a look.
Lithopone, C.I. Pigment White 5, is a mixture of inorganic compounds, widely used as a white pigment powder. It is composed of a mixture of barium sulfate and zinc sulfide. These insoluble compounds blend well with organic compounds and confer opacity. It was made popular by the cheap production costs, greater coverage. Related white pigments include titanium dioxide, zinc oxide (zinc white), zinc sulfide, and white lead.
Infrared analysis showed that the characteristics bands for the bare nanoparticles are still exhibited in the vitamins@P25TiO2NPs spectra, such as a wide peak in 450–1028 cm−1 related to the stretching vibration of Ti-O-Ti and other peaks in 1630 cm−1 and 3400 cm−1, which represent the surface OH groups stretching. The IR spectrum of vitaminB2@P25TiO2NPs showed signs of binding between compounds. The OH bending peak (1634 cm−1) corresponding to bare nanoparticles disappeared, and the NH2 bending band characteristic of vitamin B2 appeared (1650 cm−1). The IR spectrum of vitaminC@P25TiO2NPs also showed signs of successful functionalization. Bands at 1075 cm−1; 1120 cm−1; 1141 cm−1 were observed, which are originated by CO-C vibrations present in the vitamin C. The intense band at 1672 cm−1 is attributed to the C = O stretching in the lactone ring while the peak at 1026 cm−1 is ascribed to the stretching vibration Ti-O-C. Wide bands at 3880–3600 cm−1 are related to stretching vibration OH groups, but those disappear in the modified nanoparticles spectrum. These observations confirm the interactions between the P25TiO2NPs and the vitamins [35].