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Overall, TiO2 technology manufacturers play a crucial role in the advancement and innovation of TiO2 products. By investing in research and development, environmental sustainability, and production efficiency, manufacturers are able to produce high-quality TiO2 products that meet the evolving needs of their customers. With the continuous development of new technologies, TiO2 manufacturers are well-positioned to lead the market and drive further growth in the TiO2 industry.

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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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The conventional surface treatment methods of titanium alloy include glow discharge plasma deposition, oxygen ion implantation, hydrogen peroxide treatment, thermal oxidation, sol-gel method, anodic oxidation, microarc oxidation, laser alloying, and pulsed laser deposition. These methods have different characteristics and are applied in different fields. Glow discharge plasma deposition can get a clean surface, and the thickness of the oxide film obtained is 2 nm to 150 nm [28]. The oxide film obtained from oxygen ion implantation is thicker, about several microns [914]. Hydrogen peroxide treatment of titanium alloy surface is a process of chemical dissolution and oxidation [1516]. The dense part of the oxide film is less than 5 nm [1721]. The oxide film generated from the thermal oxidation method has a porous structure, and its thickness is commonly about 10-20 μm [2225]. The oxide film from the sol-gel method is rich in Ti-OH, a composition that could induce apatite nucleation and improve the combining of implants and bone. It has a thickness of less than 10 μm [2628]. Applied with the anodic oxidation method, the surface can generate a porous oxide film of 10 μm to 20 μm thickness [2931]. Similarly, the oxide film generated from the microarc oxidation method is also porous and has a thickness of 10 μm to 20 μm [3233].

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