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Titanium dioxide's journey into the food industry began with its classification as Generally Recognized As Safe (GRAS) by the US Food and Drug Administration (FDA). This status is granted after rigorous scientific evaluation, ensuring that the substance does not pose any significant health risks when used as intended. In Europe, the European Food Safety Authority (EFSA) also approves its use, but with specific guidelines on maximum levels.

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In a 2021, Chinese researchers examined the impact of E171 on lipid digestion and vitamin D3 bioaccessibility in a simulated human gastrointestinal tract model. They examined Vitamin D’s bioaccessibility, or the amount it was released in the gastrointestinal tract, becoming available for absorption, and found it “significantly decreased from 80% to 74%” with the addition of E171. In the experiment, E171 decreased lipid digestion dose-dependently. Researchers wrote: “The findings of this study enhance our understanding toward the potential impact of E171 on the nutritional attributes of foods for human digestion health.”  The study was published in the Journal of Agricultural and Food Chemistry

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