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Lithopone is rather nontoxic, due to the insolubility of its components. It has been used in medicine as a radiocontrast agent. Lithopone is allowed to be in contact with foodstuffs in the US and Europe.[1]
As of August 7, the use of titanium dioxide in food is banned in the European Union. Europe is taking a precautionary principle approach based on findings from the European Food Safety Authority (EFSA).