In terms of dietary exposure, titanium dioxide is often used in a variety of food categories, including bakery products, soups, broths, sauces, salads, savoury based sandwich spreads and processed nuts. It is also used in confectionary, chewing gum, food supplements and cake icing.

Lithopone B301, Lithopone B311 powder is also widely applied in paints and enamels

TiO₂ comes in many different forms. However, only a few of these forms are considered food-grade (acceptable to be added to food). Many studies that raised concern about the safety of TiO₂, including the concern for genotoxicity, used forms of TiO₂ that are not considered acceptable for use in food and have different properties than food-grade TiO₂. Other studies did use food-grade TiO₂, but took steps to break the material down into smaller particles than what would normally be found in food.

Importance in Factory Settings

There’s also concern that exposure to the mineral over time, even in small amounts, can build up in the body, particularly in the kidneys, spleen and liver. Although most of the mineral is excreted in feces, there is evidence that a small percentage may remain in bodily organs.