One of the main challenges that manufacturers face when it comes to buff percentage is ensuring consistency. Variations in the level of coating on titanium dioxide particles can lead to differences in color, opacity, and other properties in the final product. This can be especially problematic in industries such as paint and coatings, where consistency is critical for achieving the desired results.

In a study published in 2022 in the journal Particle and Fibre Technology, researchers examined the impact of maternal exposure to titanium dioxide nanoparticles in newborn offspring mice. They found that “a chronic exposure to TiO2 NPs during pregnancy alters the respiratory activity of offspring, characterized by an abnormally elevated rate of breathing.” Breathing was also shown to be “significantly and abnormally accelerated,” and the ability for neural circuitry to effectively adjust breathing rates was impaired. The researchers concluded: “Our findings thus demonstrate that a maternal exposure to TiO2 NPs during pregnancy affects the normal development and operation of the respiratory centers in progeny.”