In order to evaluate the penetration of the nanoparticles, eight adult male Wistar rats (3 months old) were used for the in vivo experiments. The protocol was approved by the local University Committee for animal testing and is in accordance with the Canadian Council on Animal Care (CICUAL-RD-2021–892-E-UNC-DEC#FCQ).
EFSA's evaluation is related to the risks of TiO2 used as a food additive, not to other uses.
Total zinc and barium sulphate
Anatase titanium dioxide is a popular ingredient in coatings due to its excellent UV resistance and chemical stability. Many manufacturers and businesses rely on wholesale suppliers to provide high-quality anatase titanium dioxide for their coating applications.
Titanium dioxide is often listed in the ingredients list on the product label when used in home, beauty and personal care products.
Food safety experts in the European Union (EU) have recently updated their safety assessment of TiO2 as a food additive. In Europe, TiO2 is referred to as E171, in accordance with European labelling requirements for food additives. The EU expert panel took into account toxicity studies of TiO2 nanoparticles, which to this point had not been considered relevant to the safety assessment of TiO2 as a food additive.