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Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

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Regardless of the process used, the production of titanium dioxide is tightly controlled to ensure consistent quality and to meet stringent environmental regulations. Modern facilities are equipped with advanced pollution control technologies to minimize emissions and waste. Additionally, the industry has made strides in developing more sustainable practices, such as using solar energy to power some of the reactions or recovering and recycling byproducts.

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