estimation of sulphate as titanium dioxide manufacturer

In 2019, EFSA published a statement on the review of the risk related to the exposure to food additive titanium dioxide (E171) performed by the French Agency for Food, Environment and Occupational Health Safety (ANSES). In its statement, EFSA highlighted that the ANSES opinion reiterated the uncertainties and data gaps previously identified by EFSA and did not present findings that invalidated the Authority’s previous conclusions on the safety of titanium dioxide.

...

What Is Titanium Dioxide?
Titanium dioxide, also called titania, is an odorless white powder and naturally occurring mineral that is widely used as a pigment for its brightness and whitening effects on a variety of materials, such as paint, plastic, paper, cosmetics, sunscreens, toothpastes and foods.
It’s produced through the sulfate or chloride process, which both involve treating titanium ore with sulfuric or hydrochloric acid to produce titanium sulfate or titanium chloride. These materials are then further processed to remove impurities and produce titanium dioxide in its final form.
Food-grade titanium dioxide differs from what’s added to plastics and paints to enhance whiteness. However, there have been concerns about the environmental impact of titanium dioxide production and the potential health risks from exposure to its particles.
Although food-grade titanium dioxide must be 99 percent pure, there’s still a risk of it containing potential contaminants, such as mercury, lead and arsenic. Additionally, inhaling the mineral over time can possibly cause it to build up in your body, leading to adverse effects.
Uses

...