A significant body of research, mostly from rodent models and in vitro studies, has linked titanium dioxide with health risks related to the gut, including intestinal inflammation, alterations to the gut microbiota, and more. It is classified by the International Agency for Research on Cancer (IARC) in Group 2B, as possibly carcinogenic to humans.

In conclusion, lithopone is an important white pigment that is used in a variety of industries around the world. With 30% of the world's lithopone factories located in China, the country has become a major player in the global lithopone market. Chinese manufacturers are able to produce high-quality lithopone at a competitive price, making it an attractive option for companies looking to reduce their production costs. Despite the challenges of production, China's lithium industry continues to thrive and innovate, ensuring a stable and reliable supply of this essential pigment for years to come.

In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.”  The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.

The landscape for anatase titanium dioxide manufacturers is evolving rapidly, driven by technological advancements and a shift towards sustainability. As industries continue to recognize the unique properties and benefits of anatase TiO2, the demand for high-quality products is expected to grow. Manufacturers that can innovate and adapt to changing market needs while maintaining environmental responsibility will emerge as leaders in this dynamic sector. The future of anatase titanium dioxide is bright, with promising opportunities across various industries committed to harnessing its potential for a greener future.

FAQ – EFSA 2021 safety assessment of titanium dioxide (E171)

Lithopone B301, Lithopone B311 powder is widely used in coatings, printing ink, rubber, plastic industry, etc.