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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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 At present, Lide powder is mainly produced in China. Most of the domestic Lide powder production is still using traditional methods. The main raw materials are zinc oxide, sulfuric acid and barium sulfide (barite and coal are produced by high temperature reduction). Zinc 45% ~ 70%. The traditional method for producing the Liede powder process is to use zinc bakelite containing more than 45% zinc as a raw material to be leached with sulfuric acid to obtain a crude zinc sulfate solution, and then to remove iron by potassium permanganate, and then replace the heavy metal with zinc powder and filter to obtain zinc sulfate. The refined liquid is further subjected to metathesis reaction, pressure filtration, calcination, rinsing, drying, and pulverization with strontium sulfide to obtain a series of different types of lindose powder containing zinc sulfide of 30% or more. The whole process is carried out in an acidic (ra<7) environment, which consumes a large amount of sulfuric acid. The sulfuric acid has strong corrosiveness and requires high production equipment. The final discharged slag is acidic slag, which brings new pollution to the environment. High requirements, high production costs, and poor quality of the products obtained.

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