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Leading titanium dioxide manufacturers have started to explore alternative synthesis routes that minimize waste and reduce energy consumption. For instance, some have turned to the sol-gel process, which allows for the production of nanoparticles at lower temperatures with better control over the particle size distribution. Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material use Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material use Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material use Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material usetitanium dioxid manufacturer.

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Separately, concerns have been raised about titanium dioxide impacting one's genetic code. This can be traced to a 2009 study which found that titanium dioxide nanoparticles caused DNA damage and genetic instability in mice. A 2022 study published in Food and Chemical Toxicology also raised concerns about the DNA-damaging effects of titanium dioxide as a food additive. The study noted that results evidenced a DNA-damaging effect, and added that there may also be impacts to chromosomal integrity, an indicator of cancer risk.

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