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In a review published in 2022 in the journal Archives of Toxicologyresearchers found that the ingestion of E171 is a “a definite health risk for consumers and their progeny.” After reviewing dozens of in vivoex vivo and in vitro studies on the toxicity of E171, the researchers wrote that two facts must be noted: “First, reprotoxicity studies show that animals of both sexes are impacted by the toxicity of these nanoparticles, underlining the importance of conducting in vivo studies using both male and female animals. Second, human exposure begins in utero via maternal-fetal transfer and continues after birth by breastfeeding. Children are then chronically re-exposed due to their food preferences. To be relevant to the human in vivo situation, experimental studies should therefore consider nanoparticle exposure with respect to the age or life period of the studied population.”

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Titanium dioxide production begins with the extraction of raw materials, typically ilmenite or rutile, from mines. In a white titanium dioxide factory, these minerals undergo a rigorous refining process that includes steps like sulfuric acid digestion, chloride process, or sulfate process, depending on the factory's technology and resources. The resulting titanium dioxide pigment is then purified, dried, and ground to achieve the desired particle size and quality.

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