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This work was supported by SECyT-UNC Consolidar tipo I [2018-2021] and FONCyT, Argentina [grant number 0821-2014]. MVV holded a EVC-CIN scholarship from SECyT UNC. AM, MFPP AND MFC hold CONICET, FONCyT and SECyT scholarships respectively, and MJS, AZ, VA, MFP and MCB are career members of CONICET.
In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.” The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.