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The gastrointestinal tract is a complex barrier/exchange system, and is the most important route by which macromolecules can enter the body. The main absorption takes place through villi and microvilli of the epithelium of the small and large intestines, which have an overall surface of about 200 m2. Already in 1922, it was recognized by Kumagai, that particles can translocate from the lumen of the intestinal tract via aggregation of intestinal lymphatic tissue (Peyer’s patch, containing M-cells (phagocytic enterocytes)). Uptake can also occur via the normal intestinal enterocytes. Solid particles, once in the sub-mucosal tissue, are able to enter both the lymphatic and blood circulation.

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The demand for TiO2 has been steadily increasing over the years, driven by the growth of the paint and coatings industry, as well as the expansion of its use in other applications such as electronics and cosmetics. In addition, the increasing awareness of the environmental impact of traditional production methods has led to a growing interest in more sustainable production techniques, such as the use of bio-based feedstocks or the implementation of closed-loop processes.

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