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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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In conclusion, titanium dioxide factories play a crucial role in the world's economy, contributing to a wide range of products that touch our daily lives. Their commitment to sustainability, innovation, and safety sets a benchmark for the chemical industry, ensuring the responsible production of this essential compound. As the demand for TiO2 continues to grow, these factories will continue to evolve, driving progress and shaping the future of the industry.

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