2. Mentality: the buyer has to prepare goods in advance, and the new order price is slightly less willing to purchase in bulk; Because the seller's inventory is small, the manufacturer has no willingness to reduce the price of sales.Trend: The load of titanium dioxide enterprises is stable, the willingness to ship at low prices is not strong, and the downstream buyers place orders in the early stage to establish inventory, and the short-term supplementary orders after the holiday are less. Anatase titanium dioxide due to the overall volume of the market supply side is less, the space for quotation negotiation is small, and the focus of new orders will move up. It is expected that the titanium dioxide market today just needs to be closed, and the market trading atmosphere is relatively light.

TiO₂ is also used in oral pharmaceutical formulations, and the Pharmaceutical Excipients handbook considers nano-sized TiO₂ a non-irritant and non-toxic excipient. Despite the fact that TiO₂ submicron- and nano-sized particles are widely used as food and pharmaceutical additives, information on their toxicity and distribution upon oral exposure is very limited.

For a review published in 2023 in the journal Environmental Pollution, researchers examined E171 as a possible factor promoting obesity-related metabolic disorders. Because gut microbiota play an important role in immune function maintenance and development, and because titanium dioxide as a food additive has been shown to alter gut microbiota, researchers wanted to review “the dysregulations along the gut microbiota-immune system axis after oral TiO2 exposure compared to those reported in obese or diabetic patients, and to highlight potential mechanisms by which foodborne TiO2 nanoparticles may increase the susceptibility to develop obesity-related metabolic disorders.” The study authors discovered recurrent changes in the gut microbiota composition when exposed to titanium dioxide nanoparticles, with an imbalance of intestinal symbiotic microbiota. These changes and imbalances were also reported and played a role in the development of obesity, the authors wrote. This highlights “foodborne TiO2 nanoparticles as an endocrine disruptor-like chemical promoting obesity-related disorders,” the authors concluded.