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Drobne et al. used the terrestrial arthropod Porcellio scaber as a test organism for determining the cytotoxic effect of TiO2 NPs (anatase). The animals were exposed to TiO2 NPs of two different sizes (25 nm and 75 nm) in the concentration range 10–1000 μg TiO2/g dry food for 3 to 14 days. No adverse effects, such as mortality, body weight changes or reduced feeding, were observed. In fact, quite the opposite, an enhanced feeding rate, food absorption efficiency and increase in catalase activity were observed. The intensity of these responses appeared to be time- but not dose-dependent. It should also be noted that the concentrations tested in this study were much higher than the predicted concentration (4.8 μg/g soil) at high emission scenario of nano-sized TiO2. Using the same test organism another group showed that exposure to TiO2 NPs induced destabilization of cell membrane in the epithelium of digestive glands isolated from exposed animals. They also showed that this effect can be observed after just 30 minutes of exposure.

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Anatase titanium dioxide (TiO2) is a widely used food-grade additive that imparts various functionalities to food products. It is a naturally occurring mineral that has been extensively studied for its safety and effectiveness in food applications. TiO2 is classified as GRAS (Generally Recognized As Safe) by the FDA (Food and Drug Administration) and is approved for use in a wide range of food products, including beverages, confectionery, and pharmaceuticals.

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In conclusion, the top 20 TIO2 manufacturers have made significant contributions to the growth and development of this revolutionary material. Their innovative products and solutions have helped various industries achieve their goals while also contributing to the advancement of technology as a whole. As the demand for TIO2 continues to rise, these manufacturers will undoubtedly play a crucial role in shaping the future of this exciting field.

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