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The functions of lithopone in coatings: it is mainly used in water-soluble coatings (water-soluble coatings, wall coatings), blending paint as topcoat (with reasonable high paint adhesion, excellent circulation and long storage capacity), all kinds of methyl cellulose paint (can be applied to wooden furniture such as furniture and small toys) Alkali resistant coatings based on isopropyl titanate vulcanized rubber and polyurethane materials. Also because of its excellent paint adhesion, aging resistance, acid resistance and leveling, for the production of lacquered cloth color pigments look better. It can also be used in electrophoretic coating and optical guiding system software.

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Another important factor that can impact the cost of titanium dioxide is market demand. If there is a high demand for titanium dioxide, suppliers may increase their prices in order to maximize their profits. Conversely, if there is a decrease in demand, suppliers may lower their prices to remain competitive in the market. Additionally, economic factors such as inflation and exchange rates can also play a role in determining the cost of titanium dioxide.

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One of the key factors affecting TiO2 manufacturing is the choice of raw materials. Rutile and anatase are the two most common forms of TiO2, each with its own unique properties and applications. Rutile is known for its higher refractive index and hardness, making it suitable for use in coatings, plastics, and other high-performance applications. Anatase, on the other hand, has better photocatalytic activity and is often used in environmental protection and solar energy applications.

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The production of ROS was studied on white blood cells as a model to screen the effect on eukaryotic cells after being exposed to samples and solar simulated irradiation (according to the level of penetration under the skin). For that purpose, the leukocytes were separated from anticoagulated fresh blood using the Ficoll-Hypaque reactive in a well-known technique [33]. Then, 50 μL of suspensions of P25TiO2NPs (0.2 mg/mL and 0.02 mg/mL), vitaminB2@P25TiO2NPs (0.2 mg/mL and 0.02 mg/mL) and vitamin B2 (0.2 mg/mL and 0.02 mg/mL) were prepared and mixed with 50 μL of white blood cells suspension. A solution of 3% H2O2 was used as positive control and PBS as negative control. Then, the samples were irradiated using the LED panel for 3 and 6 h to simulate the light penetration into the skin. Also, a set of samples was kept in the dark as control. Finally, the ROS were detected through the colorimetric assay employing the nitroblue tetrazolium salt (NBT salt) and the absorbance at 650 nm was measured. The experiment was reproduced twice; the standard deviation was calculated and p-value < 0.05 were considered significant.

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