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For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”

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TiO2 is also known for its high refractive index, which means that it has the ability to bend and reflect light effectively. This property makes TiO2 an ideal pigment for enhancing the color and print quality of paper products. By using TiO2 in the paper manufacturing process, paper suppliers can achieve vibrant colors and sharp images that stand out on the page. This is particularly important for printed materials such as magazines, brochures, and packaging, where visual appeal is a key factor in attracting consumers.

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