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In conclusion, titanium dioxide is an essential ingredient for plastic manufacturers due to its ability to enhance the appearance, improve mechanical properties, block UV radiation, and ensure safety and sustainability. While there may be challenges associated with its use, the benefits far outweigh the drawbacks. As such, it remains a popular choice among manufacturers who strive to produce high-quality plastic products that meet consumer demands and environmental standards.

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For research published in 2022 study in the journal Food and Chemical Toxicology, scientists examined “the genotoxicity and the intracellular reactive oxygen species induction by physiologically relevant concentrations of three different TiO2 nanomaterials in Caco-2 and HT29-MTX-E12 intestinal cells, while considering the potential influence of the digestion process in the NMs’ physiochemical characteristics.” They found a “DNA-damaging effect dependent on the nanomaterial,” along with the micronucleus assay suggesting “effects on chromosomal integrity, an indicator of cancer risk, in the HT29-MTX-E12 cells, for all the tested TiO2 nanomaterials.” Researchers concluded that the results showcase “evidence of concern” regarding titanium dioxide used as a food additive.

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