yellow titanium dioxide

Scientists analyzed research that examined how titanium dioxide nanoparticles interact with the brain for a 2015 review published in Nanoscale Research Letters. The researchers wrote: “Once the TiO2 NPs are translocated into the central nervous system through [certain] pathways, they may accumulate in the brain regions. For their slow elimination rates, those NPs could remain in the brain zones for a long period, and the Ti contents would gradually increase with repeated exposure.” After reviewing dozens of studies, the scientists concluded: “Long-term or chronic exposure to TiO2 nanoparticles could potentially lead to the gradually increased Ti contents in the brain, which may eventually induce impairments on the neurons and glial cells and lead to CNS dysfunction as a consequence.”

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The primary concern surrounding the use of TiO2 in food is its potential to be inhaled or ingested. While TiO2 is generally recognized as safe for consumption by the US Food and Drug Administration (FDA), there are some studies that suggest that it may have adverse effects on human health when consumed in large quantities over a long period of time. These studies have linked TiO2 to respiratory problems, such as inflammation and irritation, as well as potential carcinogenic effects.

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