Additionally, the committee noted that the available data did not provide convincing evidence of genotoxicity for titanium dioxide as a food additive, but recognized the limitations in current methodologies with respect to the testing of poorly soluble particulate materials. Although there were uncertainties in the genotoxicity data, the experts took into account the fact that the additive was not carcinogenic in adequately conducted two-year studies in mice and rats at doses of up to 7,500 mg/kg BW per day for mice, and 2,500 mg/kg BW per day for rats, the highest doses tested. There was also no evidence of reproductive or developmental toxicity in studies in rats at doses up to 1,000 mg/kg BW per day, the highest doses tested.  

Lithopone or sulphide of zinc white has been in general use for twenty years or more in many industries where a white pigment of considerable body or hiding power is required that is not subject to change like lead carbonate and has not the brittle character of zinc oxide, besides being sold at a lower figure than either of these. Nevertheless it is still comparatively new to the general painting trade. Because of our tariff protection its manufacture in this country has made great progress. Yet in spite of this and the duty imposed on it, the imports are still in excess of the quantity manufactured here. A short history of its origin will no doubt prove of interest to our readers.

Research supports that applying titanium dioxide to the skin in the form of sunscreens, makeup, and other topical products does not pose any health risks.