titanium dioxide filler

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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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Manufacturers of products with titanium dioxide play a critical role in the industry by ensuring that their products meet the highest quality and safety standards. These manufacturers must adhere to strict guidelines set forth by regulatory agencies to ensure that their products are safe for consumer use. Additionally, manufacturers must also invest in research and development to continually improve their products and stay ahead of the competition.

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