In the paper industry, art painting supplies level, use as a white opaque pigment for a variety of printing paper filler, white pigment for pencils, watercolors, art painting.
Titanium is a common metal element frequently found throughout nature. In our environment, titanium is naturally exposed to oxygen, forming titanium oxides that we find in many minerals, dusts, sands, and soils.
In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon. There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”