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Other techniques that manufacturers may consider include spectrophotometry, which measures the absorbance of light by a sample at specific wavelengths, and atomic absorption spectroscopy (AAS), which uses a flame to atomize sample compounds and measure the absorption of light by the resulting atoms.
Recently, Yanagisawa et al. reported that the transdermal exposure (mimicking skin-barrier dysfunction or defect) of NC/Nga mice to TiO2 NPs (15, 50, or 100 nm), in combination with allergen, aggravated atopic dermatitis-like lesions through a T-helper type 2 (Th2) dominant immune response. The study also indicated that TiO2 NPs can play a role in the initiation and/or progression of skin diseases, since histamine was released, even in the absence of allergen.
