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In a 2022 study published in the Journal of Hazardous Materials, scientists wanted to examine the effects of titanium dioxide as a food additive on atherosclerosis in mice. (Atherosclerosis refers to a hardening of the arteries.) Researchers fed mice 40 mg/kg of the food additive every day for 4 months, and found that it not only altered gut microbiota but also led to a significantly increased atherosclerotic lesion area, especially in animals that consumed a high-choline western diet (HCD).

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In a preferred technical solution, 3⁄40 2 is added to the Lide powder emulsion of the metathesis reaction step, and the mass fraction of 3⁄40 2 added is 10 to 33%, and the lithopone emulsion is desulfurized (mainly hydrosulfate ion or Elemental sulfur), slowly added 3⁄40 2 until the lithopone emulsion is colorless and transparent. The obtained sulfate ion can be recycled and reused in the production process. The chemical reaction equation is: 43⁄40 2 + HS— + OH— → SO/— + 5H 2 0

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There are numerous manufacturers of titanium dioxide; the largest include Delaware-based Chemours (a spin-off of DuPont Chemical), Texas-based Kronos, and China-based Lomon Billions Group, all of which manufacture pigments for use in products like paints, coatings, and plastics. UK-based Venator is a major supplier of titanium dioxide used in food and cosmetics, along with paints, paper, plastic, and more. As a pigment, it is called Pigment White 6 (PW6), titanium white, or CI 77891. As a food additive, it is known as E171.

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