Available studies in humans and postmortem analysis of tissues suggested that the oral bioavailability of titanium dioxide in humans is very low. JECFA noted that there are currently no epidemiological studies that allow any conclusions to be drawn with respect to an association between dietary exposure titanium dioxide and human health effects.

Lithopone 30% CAS No. 1345-05-7 / Nature and stability

Titanium dioxide is the most widely used whitening pigment in the world and has been linked to adverse health effects, particularly genotoxicity and intestinal inflammation. It is applied as food coloring and a whitening agent to a wide variety of foods, including chewing gum, cakes, candies, breads and ice cream. 

Used for coloring paint, ink, rubber, etc. Inorganic white pigments are widely used as white pigments in plastics such as polyolefin, vinyl resin, ABS resin, polystyrene, polycarbonate, nylon and polyformaldehyde, as well as paints and inks. It is less effective in polyurethane and amino resins, and less suitable in fluoroplastics. It is also used for coloring rubber products, papermaking, varnished cloth, oilcloth, leather, watercolor paints, paper, enamel, etc. Used as an adhesive in the production of electric beads.