In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

In January 2022, the average price of domestic titanium dioxide in local Chinese marketplaces was 20,735 RMB/MT. Traders were more careful in purchasing goods and downstream industries purchased things on demand. As a result, the overall market demand for titanium dioxide was general.

The brands of lithopone of the normal class, that of chemical manufacture, are marketed under such names as Ponolith, Beckton White, Jersey Lily White, Oleum White, Zinc Sulphide White, all of these being of domestic manufacture, and their composition is of the 30 per cent. zinc sulphide type. The German manufacturers and exporters of lithopone make use of fancy names for their brands and here are a few examples of these and the composition of the pigment:-