The European Commission banned titanium dioxide as a food additive in the EU in 2022 after the European Food Safety Authority (EFSA) conducted an updated safety assessment of E171 and concluded the panel could not eliminate concerns about its genotoxicity. 

A dense, white, opaque pigment composed of a mixture of Zinc sulfide (30%) and Barium sulfate (70%) with trace amounts of Zinc oxide. Lithopone, first produced in 1874, was called Orr's white. The mixture of the two components is so intimate that it is hard to distinguish microscopically. Lithopone is an inert, transparent pigment which is often used as a filler or as a base for lake pigments. Lithopone was widely used in house paints in the first half of the 20th century. It was also used for some artist grounds, inks and as a filler in Paper, Leather, and Linoleum. Now lithopone has mostly been replaced by Titanium dioxide.