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In 1970, Japanese scholars studied the phase diagram of iron oxide microcrystalline formation, which laid a theoretical foundation for the preparation method of iron oxide yellow crystal seed. According to the research results, iron yellow crystal seeds can be formed under acidic or alkaline conditions. Because iron yellow is a crystal structure, in order to crystallize into pigment particles, it must first form crystal nucleus and become crystal seed, and then the crystal nucleus grows into iron yellow. Otherwise, only thin and dim color paste can be obtained, which does not have pigment properties. Acid process can be divided into iron sheet process and drop addition process.

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Both P25TiO2NPs (with or without vitamin B2) were not found beyond the epidermis in 99% of the analyzed TEM images (Fig. 8). This is coherent with previous findings showing that nanoparticles greater than 50 nm can not penetrate the skin, even in vivo models with movement, stretching, and friction [54]. However, in one of the zones, a few nanoparticles were observed inside a hair follicle. This could be due to the follicle exposure after the localized rupture of this physical barrier when rats were shaved in order to clean the area for cream topical administration. This finding suggests that nanoparticle-based sunscreen should not be applied on recently shaved or harmed skin, in order to avoid nanoparticle skin penetration.

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The blending process is a critical step in the manufacturing, where zinc sulfide and barium sulfate are thoroughly mixed to ensure homogeneity. This is often done using specialized equipment like ball mills or attritors, which grind the particles to an ultrafine consistency, enhancing the pigment's opacity and whiteness This is often done using specialized equipment like ball mills or attritors, which grind the particles to an ultrafine consistency, enhancing the pigment's opacity and whiteness This is often done using specialized equipment like ball mills or attritors, which grind the particles to an ultrafine consistency, enhancing the pigment's opacity and whiteness This is often done using specialized equipment like ball mills or attritors, which grind the particles to an ultrafine consistency, enhancing the pigment's opacity and whitenesslithopone manufacturing process manufacturer.

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