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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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In the realm of pigments, titanium dioxide's ability to reflect light across the visible spectrum makes it an ideal candidate for brightening products. It is widely used in paints, plastics, paper, inks, food coloring, and cosmetics. The addition of TiO2 not only enhances the whiteness but also improves the durability and opacity of these materials. Moreover, its non-toxic nature ensures that it can be safely used in products that come into direct contact with humans, such as food colorants and cosmetics.

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