china white precipitate of titanium dioxide

Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation. 

...

Modern production facilities employ state-of-the-art technologies to ensure particle size distribution is optimal, which is crucial for the pigment's performance in end-use applications. Advanced filtration systems remove impurities, ensuring that the final product meets the highest purity levels. Additionally, manufacturers pay close attention to environmental concerns by implementing waste management strategies to minimize any negative impact during the production process.

...