Both calcium carbonate and titanium dioxide play crucial roles in various industries, but they are used for different purposes. Calcium carbonate is primarily used as a filler and pigment, while titanium dioxide is used as a whitening agent and pigment. Additionally, titanium dioxide is more expensive to produce than calcium carbonate due to its synthetic nature and complex manufacturing process.

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Research has shown that, when ingested as a food additive, titanium dioxide and its nanoparticles can impact, alter, and/or damage important protective bacteria in the gut, along with the metabolic pathways of gut bacteria.