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In a 2017 study published in Scientific Reports, researchers exposed rats to human-relevant levels of E171 to examine the effects of intestinal inflammation and carcinogenesis. They saw that “a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model.” They continued: “Stimulation of immune cells isolated from Peyer’s Patches [which are clusters of lymphoid follicles found in the intestine] showed a decrease in Thelper (Th)-1 IFN-γ secretion, while splenic Th1/Th17 inflammatory responses sharply increased,” researchers wrote. “A 100-day titanium dioxide treatment promoted colon microinflammation and initiated preneoplastic lesions.” The scientists concluded: “These data should be considered for risk assessments of the susceptibility to Th17-driven autoimmune diseases and to colorectal cancer in humans exposed to TiO2 from dietary sources.”

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In 2023, the demand for titanium dioxide is expected to reach new heights. One of the main drivers of this growth is the cosmetics and personal care industry. Titanium dioxide is widely used in sunscreens, skin care products and cosmetics for its excellent UV protection properties and ability to provide a smooth surface. With growing awareness of the harmful effects of UV radiation, consumers are increasingly inclined to invest in products with sun protection. This trend is expected to drive the demand for titanium dioxide over the next few years.

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Moreover, the safety measures in these factories are paramount. Workers are equipped with protective gear and trained to handle potentially hazardous chemicals safely Workers are equipped with protective gear and trained to handle potentially hazardous chemicals safely Workers are equipped with protective gear and trained to handle potentially hazardous chemicals safely Workers are equipped with protective gear and trained to handle potentially hazardous chemicals safelyr 5566 titanium dioxide factories. Stringent regulations, such as OSHA standards in the US and EU REACH guidelines, ensure that these factories operate responsibly and ethically.

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