Most notably, a European Food Safety Authority safety assessment published in May 2021 pointed to genotoxicity concerns, as suggested by previous research. Genotoxicity is the ability of chemicals to damage genetic information such as DNA, which may lead to cancer.

Moreover, titanium dioxide is also used in rubber formulations to improve the processing and curing properties of rubber compounds. It acts as a catalyst in the vulcanization process, speeding up the cross-linking of rubber molecules and enhancing the overall performance of the final product. This results in rubber products that are stronger, more flexible, and better suited for a wide range of applications.

Rutile titanium dioxide R-996, white powder, insoluble in water, non-physiological toxicity, stable chemical properties, surface coated with silicon, aluminum, zirconium and organic treatment has excellent pigment performance, whiteness, brightness, good gloss; Strong hiding power, achromatic power and fluidity Rutile titanium dioxide, white powder, insoluble in water, non-physiological toxicity, stable chemical properties, excellent pigment performance after the surface is coated with silicon, aluminum, zirconium and organically treated, whiteness , Brightness, good gloss, hiding power, achromatic power and fluidity are strong, with excellent weather resistance and anti-powder properties.

Testing samples were made mixing 100 uL of TiO₂NPs suspensions (0.2 mg/mL and 0.02 mg/mL) and vitamins@P25TiO₂NPs (0.2 mg/mL and 0.02 mg/mL) with 100 μL ATCC 29,213 methicillin-sensitive Staphylococcus aureus (MSSA) (10⁷ in PBS, pH 7). Controls were made replacing nanoparticles with the same volume of PBS. The concentrations of nanoparticle suspensions were chosen based on the FDA approved maximal and the minimal amount usually found in sunscreens, which are 20% and 2% (this is equivalent to 0.2 mg/mL and 0.02 mg/mL for nanoparticles suspensions). The cream concentration, on the other hand, was an intermediate value of 10%.

In a study published in 2022 in the journal Particle and Fibre Technology, researchers examined the impact of maternal exposure to titanium dioxide nanoparticles in newborn offspring mice. They found that “a chronic exposure to TiO2 NPs during pregnancy alters the respiratory activity of offspring, characterized by an abnormally elevated rate of breathing.” Breathing was also shown to be “significantly and abnormally accelerated,” and the ability for neural circuitry to effectively adjust breathing rates was impaired. The researchers concluded: “Our findings thus demonstrate that a maternal exposure to TiO2 NPs during pregnancy affects the normal development and operation of the respiratory centers in progeny.”