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In conclusion, lithopone pigments, as manufactured by dedicated producers worldwide, are integral to numerous industries. Their production involves a complex yet precise process, and the manufacturers' continuous efforts to enhance product quality and sustainability ensure the ongoing relevance of lithopone pigments in the global market. With the increasing demand for efficient and environmentally friendly materials, the future of lithopone pigments as a key pigment choice appears promising.

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A  2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

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