Lithopone is produced by coprecipitation of barium sulfate and zinc sulfide. Most commonly coprecipitation is effected by combining equimolar amounts of zinc sulfate and barium sulfide:

Titanium dioxide (TiO2) is used in a variety of personal care products, including sunscreens, pressed powders, and loose powders, as a UV filter or whitening agent. In lotions and creams (dermal exposure), it is not a risk for adverse health effects. However, when titanium dioxide is inhalable—as it may be when in powder form—it is considered a possible carcinogen by the International Agency for Research on Cancer.Titanium dioxide nanoparticles do not appear to confer any unique health hazards.

Titanium dioxide R-5566 can be widely used in indoor and outdoor coatings, latex paints, powder coatings, inks, papermaking, rubber, plastics, masterbatches.